Metabolic Dysfunction–Associated
Steatohepatitis (MASH)

Chronic Liver Stages

A Chronic Liver Disease

MASH is a leading cause of liver-related mortality and an increasing burden on global healthcare systems.

The Role of Thyroid Hormone Receptor β (THR-β) in MASH

In MASH, reduced signaling via THR-β exacerbates hepatic mitochondrial dysfunction, inflammation, and fibrosis.

role of thyroid updated
role of thyroid updated

The Role of Thyroid Hormone Receptor β (THR-β) in MASH

In MASH, reduced signaling via THR-β exacerbates hepatic mitochondrial dysfunction, inflammation, and fibrosis.

Melody.education

Melody.education

Learn more about MASH with educational programs and podcasts (non-CME) presented by leading 
MASH experts. Be sure to become a member to receive regular updates on new content and test your knowledge with Clinician Challenge questions.

COMING SOON

Our Research

MAESTRO Clinical Development Program

Our clinical development program focuses on a thyroid hormone receptor-β (THR-β) agonist being studied for the treatment of MASH.

Publications

View key resmetirom and clinical publications along with recent congress presentations.